I have Major Depression, recurrent. I take Prozac for my depression, I’ve tried several others but Prozac works best for me. I also take Effexor, low dose, to help cope with the hot flashes and other side effects of the drug I’m on to try to prevent a return of breast cancer. Recently I have found that my depression gets worse in the evening, I hate to see the evening come aound. Does anyone else experience this and if so how do you cope? Right now my depression is a little worse but I think it’s due to having had open heart surgery 7 weeks ago.