Wife of 42 years, upbeat, highly functional, healthy, vibriant, happy, has shown a progressive downhill course in the past year or so. Now sleeps most of the day, likes the temp cold, eats more…has gained 10 to 12 pounds in past 6 months, stopped exercising, loss of interest, three minor MVA in 2011, has not made a meal in over 4 months (was an excellent cook), no desire to go out …to dinner or movies, etc. Begins to focus on one illness and then another to explain her problems. I feel she has memory loss and/or confusion yet she refuses to be tested. PET/CT reveals frontal-paritiall hypo- metabolism, MRI reveals mild cortical atrophy. Recent Neuro consult…Dx. Depression. My impression after living with her for the past 42 years is “He is way off base.” Need help?