I've been prescribed the Big 3 for MAI. In addition to nodules, I have one lung cavity (16×9 mm), and I take ethambutol and rifampin daily and azithromycin on MWF. The directions are to take the azithromycin and ethambutol one hour before breakfast and the rifampin two hours after dinner. I've been taking them for three weeks. Is there any reason I can't take all three at the same time at night? Does anybody do this? The reason I ask is because the ones I take in the morning seem to knock me out for several hours after breakfast, and I'm thinking if I take them all in the evening I might avoid this.