Last March, I was diagnosed with multiple cytochrome P450 drug metabolization polymorphisms by Mayo Rochester’s Pharmacogenomics group. (In a nutshell, because of genetic polymorphisms in my liver enzyme system, I do not properly-metabolize most medications.)
Though I’m very thankful for finally having an answer to why I was becoming increasingly more and more ill for 12 years, it’s extremely difficult to find any information about this condition:
• I cannot locate any information regarding the clinical symptoms of having these polymorphisms.
• These polymorphisms are not rare, so I continue to remain stunned that pretty much no one in the medical community has a clue about this issue. Most doctors have nothing beyond a rudimentary understanding based on some P450 info they learned in their first few years of college.
• I cannot find information regarding the possible long-term affects on the body of taking P450 medications when you cannot properly-metabolize them.
At this point, I’ve learned about this via my own research (thank god for the Internet), and actually have to educate my own doctors regarding how to figure out whether or not they can or cannot prescribe a medication for me.
Does anyone know about any good resources for finding information about this issue, or has anyone ever been diagnosed with these? I want to prevent people from having to go through what I went through; this was a horrible experience that almost killed me, and I am certain that many, many people are also suffering from this in a widespread fashion. I’m working to compile information from legitimate sources, as well as a symptom list, to create an online support group.