Considerations about a doublet versus triplet therapy

Posted by Jeff Marchi @jeffmarc, Sep 13, 2025

Here is some information I just read that discusses reasoning and side effects of doublet versus triplet therapy. The table at the bottom outline some of the major issues from different treatments.

I’ve never seen a breakdown like this that really discusses the issues with taking different advanced treatments

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Thanks for sharing that. I think the key point is in the text before the table:

1. Doublet therapy for low-volume (oligometastatic) advanced prostate cancer
2. Triplet therapy for high-volume (polymetastatic) advanced prostate cancer.

It aligns well with what we've been discussing and referencing here in the forum for the last while. With the doublet therapy, you'd also have radiation treatment to the individual metastases and the prostate itself.

REPLY
Profile picture for northoftheborder @northoftheborder

Thanks for sharing that. I think the key point is in the text before the table:

1. Doublet therapy for low-volume (oligometastatic) advanced prostate cancer
2. Triplet therapy for high-volume (polymetastatic) advanced prostate cancer.

It aligns well with what we've been discussing and referencing here in the forum for the last while. With the doublet therapy, you'd also have radiation treatment to the individual metastases and the prostate itself.

Jump to this post

I thought the table at the bottom with side effects was pretty interesting for people that are not familiar with the different treatment treatments.

REPLY

Yes, this is clear and consise. The table is a nice reference to see all. The Docetaxel edema syrprised us as not everyone experiences it - will probably post about it in another thread.

REPLY

Just fyi, my husband had no edema with docetaxel.

REPLY
Profile picture for lag @lag

Just fyi, my husband had no edema with docetaxel.

Jump to this post

That is great to hear! The fewer the side effects, the better, right?

REPLY

Just to make this more clear

AR antagonists: Enzalutamide, Apalutamide, and Darolutamide

GnRH antagonist drugs like abarelix, degarelix, elagolix, ganirelix, linzagolix, and relugolix These are ADT type drugs

REPLY
Please sign in or register to post a reply.