Anyone taking Hydroxyurea for ET and Prolia for Osteoporosis?

I started Prolia 1 1/2 yrs ago. I’m doing fine. 🥰

diagnosed with ET 2020 age 88 immediately started hydroxyurea twice daily morning/night. Platelets reduced but only to mid-600s as higher hydrox level knocks red cell count way down causing extreme lethargy! Anyone else have similar outcome?

Yes I am taking all 3 meds that you are. I have Jak 2 ET for 1 and have years taking hydroxyurea with 650 at a high and a low platelets of 41. Changing dosage due to fluctuations. Now taking 1 500 tablet every other day.I also take Prolia injections last 5 years and levothroxine last 5 years. I am 86 and I debated about Prolia but my rheumotologist doc convinced me and I have no issues with it.

Thanks everyone! With further reading and weighing my options, I have decided to go with weekly Fosomax tablet instead of Prolia. I feel like it fits my needs better without the worry of rebounding once I quit taking it and it just fits my situation better. Worries alleviated for now and crossing my fingers that everything works out!

I’ve been taking hydroxyurea
for my PV since 2018
Two and half years ago my rheumatologist told me my osteoporosis was severe I didn’t want injections, thinking that at least if I took a pill, I could stop if I had side effects Was on
Allendronate for two years
Things just got worse and I had a fracture. Had my first Prolia
in July Next one in December
So far, no problems Guess my next decade will tell what’s
going on. I get one every year
Best of luck to you
No side effects from the pills either

I tried fosomax for 2 weeks back in 2010 and had the worst joint issues and swelling so went off. I’ve never felt so achy. About 10 years later PCP said I had to do something so we tried another variation and same issues. Finally after seeing an rheumatologist for and the reaction to the two osteoporosis drugs the insurance approved Prolia. I have been taking it for about 4 years twice a year and no issues. However I can’t go back and take the ones that build bones like Forteo which my doctor wishes we had tried first. I also started taking hydroxurea last February because platelets were over a million. They are now down into the 400’s. I am 73 ride horse, bike and lift weights. Everyone reacts differently to these drugs so good luck.

I have bern in both drugs. I am on prolia for osteopenia for 3 yrs now no problems. I was more scared of getting fractures. I fell and fractured L1 and L5 vertebrae. The worst pain I ever went through in my life. I also took hydroxy for a year. Started with 1000mg and then 500mg once a day for low platelets. I had MDS then. No problem except my red cells went down. I now have progressed to AML. I am doing the 7+3 days chemo infusions and take a chemo pill with it. I am finishing my second cycle Tuesday. I did a bone marrow biopsy that I am still waiting on results and I will do a blood test on Monday to see if it put me in remission. The treatment was not bad at all. It’s just all the medication you have to remember to take with it. I did accelerated chemo 18 yrs ago for breast cancer and 25 radiation treatments and 3 boosters. They think this might be why I have Leukemia. I trust my doctors especially my oncologist. I went 9 years with MDS before I had to start treatments. Hang in there. Prolia is fine and it prevents fractures. I had to learn not to read google. It scares you to death. Good luck.

@wisner I’ve been taking HU for ten years and yes it really caused my RBC to go low. I was suffering from mild fatigue and thought it was the HU until this year when my GP noticed I was deficient in vitamin D 3 and put me on supplements. Within days the mild fatigue was gone although my RBC stayed low. HU also would send my WBC below normal. It was quite low during the pandemic. Surprisingly I didn’t get so much as a cold and never got Covid ( I did get multiple Covid shots). I may be getting off HU in a few weeks, fyi.