Anyone have 100% PTEN loss

Posted by rwski79 @rwski79, Sep 24 1:42pm

Genetic/dna PTEN loss creates “open door” for recurring cancer. New research shows use of capivasertib plus abiraterone and prednisone “closes” that door. My recent CARIS lab report shows 100% PTEN loss. I have just started a “holiday” from Orgovyx/Nubeqa after two years undetectable PSA/ Testosterone, clear scans etc. I am Gleason 9 after prostatectomy 2024. What to do? Cut holiday “short”? Restart ADT with Capivas. Etc? Anyone have similar situation/dilema?

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gently | @gently | Sep 24 2:46pm

https://www.urologytimes.com/view/pten-loss-in-metastatic-prostate-cancer-biology-and-prognosis

Jeff Marchi | @jeffmarc | Sep 25 11:36am

If I were in your situation, I would wanna have PSA tests every month for at least six months to make sure that your PTEN issue doesn’t cause a quick reoccurrence. You can have that new treatment if it comes back, Or maybe even sooner. Something to discuss with an oncologist that specializes in prostate cancer.

rwski79 | @rwski79 | Sep 25 12:41pm

Thanks Jeff,
Great advice. I have an oncologist appointment in two weeks and will ask for monthly PSA testing. Now scheduled for every 3 months, but that was prior to CARIS findings re. PTEN. Don’t need added anxiety of waiting more than a month at a time. Thanks so much. Appreciate your input!