Sue: A few things … the Mayo citation is no longer … and the discussion about who can give the treatment does not include the fact that most prolotherapy is done by MDs who are pain specialists. I was not aware that practitioners are actually done by just anyone.
Then there is the question about what is used for prolo … in most places it is 'sugar' water, but can be other substances. The point though …it is NOT the substance that matters because the whole idea is that the punctures, not really injections, create the physical signals for the 'self-healing' to begin. The practice is mostly done by Drs who call the practice Regenerative Medicine.
Finally, success depends on several things … there are different techniques and the patient's response depends on the viability of the patient's own healing system.
I had a wonderful experience after 3+ years and many Drs. who misdiagnosed my hypermobile SIJoint. The 6th Dr's prolotherapy fixed the "lax" ligaments attached to the joint that had become disfunctional from matching the SIJoint's hypermobility, created by a leg length differential. I am hoping there will be definitive studies that will bring prolotherapy out of the shadows where it has been.