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Anyone familiar with pH balanced 7% saline, rather than acidic type?
MAC & Bronchiectasis | Last Active: Oct 30, 2022 | Replies (43)Comment receiving replies
@irenea8 I find the statement "Pseudomonas likes an acidic environment" very interesting. So I did a little research and found this article https://pubmed.ncbi.nlm.nih.gov/34867864/ It makes me wonder if the same holds true for NTM/MAC. I can't find any info on that. You have a contact number for the manufacturer of PulmoSal, would you mind calling back for more information regarding the effect of an acidic environment on Mycobacteria? Thanks, Bill
Replies to "@irenea8 I find the statement "Pseudomonas likes an acidic environment" very interesting. So I did a..."
THE ROLE OF THE CELL ENVELOPE IN ACID RESISTANCE
At an external pH of 5, the internal pH of M tuberculosis H37Ra was close to 7, indicating that mycobacteria are able to maintain a neutral internal pH in an acidic environment (105), and other studies have confirmed this observation in M. smegmatis and virulent M.22/05/2009
Acid Resistance in Mycobacterium tuberculosis - PMC - NCBIhttps://www.ncbi.nlm.nih.gov › articles › PMC2715723
Not Quite what you were after @poodledoc but quite interesting.
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Hello Bill, The only information I have seen that this manufacturer has put out is about Pseudomonas. The studies were done in vitro but it did seem that Pseudomonas was better controlled using a less acidic saline. So worth a try for me! If they have information about NTM/MAC i would not know but i do not think so. Here is their website.
https://www.pharmacaribe.com/our-products/ordering-information/