Prolotherapy is an old treatment seeing a resurgence. Usually the substance used is a glucose solution, but it may be combined with other ingredients. Some factors to be aware of include: This is an unregulated treatment, so may be done by any practitioner allowed to do injections, without special training or qualifications. Prolotherapy appears to be more effective if the injections are done by a skilled pain injection practitioner who has skill in placing therapeutic substances exactly where needed for a specific condition. Therapy appears to be more successful when combined with other treatment such as stretching or PT.
The following is a lengthy review of studies of pain reduction from prolotherapy – only one addresses SI joint pain directly, and shows improvement in about 50% of people at 15 months (you would need to locate & read the complete study to see how many injections, adjunct therapy, etc.)
In doing your research on the technique, be sure to differentiate information published by the practitioners and those published by an independent group.
What practitioner has recommended prolotherapy to you? Have you already tried more conservative therapies including ice, stretching and physical therapy?