The endocrinologist I saw was adamant that fat is a very active 'system, the complexity of which science is only now relooking at. And that, at least in women, it's a big contributor to estrogen-sensitive cancers. As someone with the world's worst sweet tooth (but no metabolic syndrome makers which surprises me), 5hat is bad news. Insulin resistance is also a factor for estrogen-fueled cancers. But here's some good news. I've read, in several places including comments in the NY Times, that fasting for as little as 12 hours seems to work to increase insulin sensitivity and may help reset how insulin and fat play a role here and make it easier to tackle the weight issue. I'm sure that lockdown eating didn't help mine,