In 1996, at the age of 47, I was diagnosed PCB (by my very bright family MD)–a woman, who immediately sent me to Mayo. I was in the original trial studies for URSO and it is a good send. At the time of my diagnosis my prognosis was (due to no treatment) a decline in health and liver transplant. It was right after the death of Walter Payne from a similar disease. It was grim dx and at that time I was asymptomatic as my MD dx it so early. But despite URSO my health has gone down hill. I now have 5 autoimmune disorders as well as intractable chronic migraines and trigeminal neuralgia for which I had unsuccessful brain surgery. I have never talked/emailed anyone who had this disorder. It was not until I read the posts here that I understood my ‘hit the wall’ days when I absolutely cannot get enough sleep. I have been on disability since 1997 but continue to work part-time and do academic work (my profession). I am sorry to hear about the itching problem. For me this is minor although this year I have developed eczema which is slowing spreading across my body. It has been discouraging for someone who was super energetic and multitasking to have to ‘ratchet down’ my life and career. With my other health problems it has been difficult but I also feel grateful for an early dx and treatment. I am glad to find others on this site and I will go to PCB.org.