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gg17 (@gg17)

Cyclosporine and kidney issues

Blood Cancers & Disorders | Last Active: Nov 8, 2020 | Replies (4)

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Prior to the CLL rearing it’s head, my kidney function was good. I had creatinine levels around 1.0, but no kidney damage. I had a lot of muscle mass from exercise and weight lifting. Then after hospitalization I lost muscle mass and creatinine levels were about .8. So my GFR was 90 prior to cyclosporin. I developed AIHA, PRCA (parvo), neutropenia and thrombocytopenia (platelets remain around 100,000). The cyclosporin is for the PRCA. The CLL was knocked down in March with rituxan. I am currently seeing a specialist at Mayo. He monitors my creatinine, but I am still concerned because it has been as high as 1.5 and 1.3. Some things I have read state that cyclosporin can cause vasoconstriction and a temporary rise in creatinine. What do I believe?

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Replies to "Prior to the CLL rearing it’s head, my kidney function was good. I had creatinine levels..."

@gg17 Here is an article from Mayo Clinic about cyclosporine and nephrotoxicity https://www.mayoclinic.org/drugs-supplements/cyclosporine-oral-route/description/drg-20075815

How long has your dr said you would be on a regimen of cyclosporine? You might want to mention to him your concerns. Referring to PRCA, here is an article from the Aplastic Anemia and MDS regarding it, and the treatments https://www.aamds.org/diseases/related/pure-red-cell-aplasia-prca
Perhaps if you can research the reason for developing the PRCA, you will find a more compatible treatment to ease your mind and kidney function.

I hope this helps you a bit, so please let me know what you decide to do, will you please? Keeping a medical journal that shows a timeline of your testing/values/medication commencement or cessation will help paint a clearer picture for everyone. What type specialist are you seeing at Mayo Clinic?

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