@dablues The nasal spray given to you is classed as an antihistamine. That said, an antihistamine will usually dry up mucus membranes in more than just your eyes/nasal cavity. They can dry out your mouth and vaginal areas also. Your vaginal blood may have been a side effect of the medication, but also a sign of atrophy of vaginal tissues, which is common as we age.
Typically, foamy urine with pain on urination, is a sign of excess protein in the urine. Are you eating a lot of protein? It will shed off in urine. As for the estrogen cream, I would question the wisdom of it, what they hope to accomplish by using that. It may be time to see a gynecologist or your primary for a complete well-woman checkup. As has been mentioned, what was the cause of needing blood transfusions 3 years ago?