I think that we all relate to those concerns, but our individual circumstances vary. For example, I had a good result on my bone density test in August 2019 (at age 72), so I decided to continue anastrozole another two years, but added 500 mg of calcium/day. If it starts going downhill in 2021, I likely will reassess. I do not have any of the problem genes, so my BC (which was high in hormone receptors) likely was due to having taken hormone replacement therapy in my 40s and 50s. The trade-offs are daunting.