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@tonyinmi

@lioness, yes, it sounds scary but would be worth it if offers a cure. People with cochlear implants may have an advantage since there is an electrode array already inside the cochlea. Perhaps the delivery method would not require an injection???
Tony in Michigan

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Replies to "@lioness, yes, it sounds scary but would be worth it if offers a cure. People with..."

@tonyinmi
Hi,
I learned on Thursday that people with Cochlear implants are not candidates for the injections. Also it is only for people with acquired sensorineural hearing loss which they estimate is 90% of the population with hearing loss. The ear has to be healthy…no damage to the tympanic membrane. There are a lot of considerations as to how the fluid in the inner ear would interact with the fluid in the injection, whether a person has Menieres, what other drugs a patient is taking etc.

This is probably 5 to 10 years in the future and the clinical trials are for 18 to 65 year olds right now which are a lot of people with this hearing loss. If you have a CI in one ear you could inject the other ear. More considerations as to whether the injection is a one shot deal or a series or is ongoing.

What they basically found was that in the cochlea there are progenitor hair cells right next to the hair cells that receive sounds. In all mammals except humans, these progenitor cells send a signal to the deteriorated hair cells to regenerate. In humans, the progenitor cells act only as support for the other cells. This drug seems successful in generating a signal to wake up the other cells. They are doing double blind trials and have not experienced the placebo effect of some clinical trials in general. You can’t think you hear better if you didn’t get the drug. Your word recognition is tested and people who received the drug had improvement. Not sure how much. I got most of the info from the Q&A session afterwards.

@lioness
I get eye injections…my eye is numbed lol. I guess they would numb the ear. I would be the first in line for a clinical trial if I could.
What a major breakthrough this is.

FL Mary

Strongly suggest you to to http://www.experiencehlaa.org or to the HLAA website at http://www.hearingloss.org to learn more about this. Steroid injections are often given to people with sudden hearing loss. They are hoping to find a drug that will regenerate the cells in the inner ear that die and create sensorineural hearing loss. This clinical trial is called FX322. Researchers mentioned that you can find ongoing clinical trials at http://www.clinicaltrials.gov Many participants were interested in learning how or if they could participate in the trials. Today they will tell us what is being done in tinnitus research. The presentation is from 12 – 1:30 Eastern time. http://www.experiencehlaa.org just go to the site and click on 'register'. How fortunate we are today, to have this kind of research happening.

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