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Returning Member -- But New To This the Breast Cancer Group -- DCIS
Breast Cancer | Last Active: Feb 14, 2020 | Replies (9)Comment receiving replies
@danielad
Hi, Dee. From what I understand for postmenopausal women, most of our estrogen is produced by body fat, although at lower levels than what our pre-menopausal ovaries produced, and by our adrenal glands. Here's a related article which may be of interest to you:
https://www.breastcancer.org/research-news/total-body-fat-affects-risk-more-than-belly-fat
Replies to "@danielad Hi, Dee. From what I understand for postmenopausal women, most of our estrogen is produced..."
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@danielad (Part 2)
Regrettably, the second half of my response went haywire with the website... so let's try it, again.
As to why the risk of invasive breast cancer and ER+ disease are higher over time for those who took HRT versus never-users, for example, is not clear to me. Recently, researchers looked at a tremendous number of data and found a strong correlation, especially dependent on duration of use and excess weight (BMI).
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31709-X/fulltext
Now that the correlation has been found, perhaps the researchers will look more closely for the mechanism/s at work in all this (and it may well lie in our body fat and that enzyme aromatase?).