1. < Digestive Health

Estrogen replacement therapy helps maintain gut mucous membranes

Posted by virginia44 @virginia44, Sep 21, 2019

I recently stumbled upon a research article on the effects of estrogen on the GI tract. Not only does it help to maintain the mucosal barrier lining the tract, longer exposure to estrogen may decrease the risk of gastric cancer. I started thinking about when I went off of estrogen replacement therapy a few years ago (2016) and by looking back at prescription refill dates realized that is when I began to have serious gut problems that required constant medication. I am wondering if anyone else has had experience going on and/or off of estrogen medications, and if so, can you link that event to GI problems.

I am planning to have this discussion with my doctor, but am curious about experiences others may have with this particular issue.

Interested in more discussions like this? Go to the Digestive Health Support Group.

cim37343 | @cim37343 | Nov 18, 2019
In reply to @virginia44 "jackie, I finally got in to see my gyn doc and discussed going back on estradiol...." + (show)
@virginia44

jackie, I finally got in to see my gyn doc and discussed going back on estradiol. She had been to a conference recently and completely agreed that it maintains mucosa in other organs, and immediately put me back on it. I feel better after about 10 days on a local form of it. It's a tablet that gets inserted into vaginal area. Hope you are doing well.

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This hormone replacement therapy for IBS, etc. is great news. Thanks ladies!

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virginia44 | @virginia44 | Nov 18, 2019

If you plan to discuss this with your doctor, you may want to bring a reference for the published research paper. Here is the paper I brought: "Sex hormones in the modulation of irritable bowel syndrome". World J. Gastroenterol. 2014 Mar; 20(10) 2433-2448. There are a couple other but this one is very detailed.
I hope this is helpful.

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1 reply
cim37343 | @cim37343 | Nov 18, 2019

Great! Thanks so much!

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jackiem95 | @jackiem95 | Nov 18, 2019
In reply to @virginia44 "If you plan to discuss this with your doctor, you may want to bring a reference..." + (show)
@virginia44

If you plan to discuss this with your doctor, you may want to bring a reference for the published research paper. Here is the paper I brought: "Sex hormones in the modulation of irritable bowel syndrome". World J. Gastroenterol. 2014 Mar; 20(10) 2433-2448. There are a couple other but this one is very detailed.
I hope this is helpful.

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Thank you!!

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