@sandykayhud Hi. I searched and searched the internet to try to find the answer to your question. I have not come across anything that says that Arikayce can cause you to lose your voice permanently. It is a fairly newly released drug, so it has a short history. I had a similar thing happen to me when I first started on inhaled tobramycin. I am now very used to it and it doesn't make me hoarse any longer. It took me several weeks to get beyond the hoarse stage. Are you continueing on with it?