@brigby I was started with the Azithromycin. I think that will be better tolerated than Clarithromycin. I have been on for 18 months. I had a culture come back positive in April. Susceptibility testing shows it is still susceptible. I am going to try for another opinion at Mayo in Rochester. My weight goes up and down in a 5 pound range depending on how stressful things get and usually around times when I have MD appts, Are you on Rifampin. Do you take it with an empty stomach. Rifampin should be on empty stomach. I would certainly give the Azithromycin a try. I was told it takes a long time to get rid of it cuz it takes a long time to grow and you have to catch it in all different stages of growth.