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elsa (@elsa)

Small Fiber Neuropathy?

Neuropathy | Last Active: Jan 16 7:39am | Replies (207)

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@hotfooted Kudos for for cutting out the sugar and carbs. That is a first step to improve diabetes. Magnesium is involved in detoxing the body and most of us are deficient.

I found an article about the role of oxidative stress and diabetes that I found interesting. Oxidative stress is what you want to prevent in the body with antioxidants that are found in healthy foods. It talks about a deficiency of glutathione (which is a master antioxidant in the body) because of diabetes. It also mentions another antioxidant alpha lipoic acid and discusses doses of this that at the highest doses prevented the deficit of glutathione. According to the article, that is what is missing starting in the smallest nerve fibers, and diabetes damages the respiratory pathways where the mitochondria in the cells create energy from cellular respiration. I do know that a precursor to glutathione is N aceylcysteine which can be purchased as a supplement. It would be best to consult a functional medicine specialist on this, as too much of NAC can be bad, and possibly reverse functioning and cause oxidative stress while the correct dose will help raise the body's glutathione.

Here is a quote from the article, The Roles of Oxidative Stress and Antioxidant Treatment in Experimental Diabetic Neuropathy.
"we posit that lipid peroxidation causes mitochondrial DNA mutations that increase reduced oxygen species, causing further damage to mitochondrial respiratory chain and function and resulting in a sensory neuropathy, α-lipoic acid is a potent antioxidant that prevents lipid peroxidation in vitro and in vivo. We evaluated the efficacy of the drug in doses of 20, 50, and 100 mg/kg administered intraperitoneally in preventing the biochemical, electrophysiological, and nerve blood flow deficits in the peripheral nerves of experimental diabetic neuropathy, α-lipoic acid dose- and time-dependently prevented the deficits in nerve conduction and nerve blood flow and biochemical abnormalities (reductions in reduced glutathione and lipid peroxidation). The nerve blood flow deficit was 50% (P < 0.001). Supplementation dose-dependently prevented the deficit; at the highest concentration, nerve blood flow was not different from that of control nerves. Digital nerve conduction underwent a dose-dependent improvement at 1 month (P < 0.05). By 3 months, all treated groups had lost their deficit. The antioxidant drug is potentially efficacious for human diabetic sensory neuropathy."

Also this link has an easy to understand explanation of the roles of antioxidants and disease.

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Replies to "@hotfooted Kudos for for cutting out the sugar and carbs. That is a first step to..."

I have SFN but not diabetes and take 500mg R-ALA 2xday which I think does help along with gabapentin at night.

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