Hi@parus. I had my cheek swabbed two weeks ago and will see my psychiatrist in three weeks for the reading of the leaves. My understanding is that there are a few specific enzymes that determine how one metabolizes anti-depressants. The presence of these enzymes, or absence, do not point to one specific drug, but does offer guidance to the potential for one or more to be effective and also guidance regarding those that in all likelihood would not be effective. The other aspect of managing medications is the clues the doctor will get toward how one's metabolism (again, specific enzymes present or not) will relate to a particular anti-depressant. The major guide here is what dosage will be most effective. If you metabolize a drug quickly, you will need a larger dose and vice versa. I have discovered that there are some meds that actuate at lower dosages better than at higher and that is generally true of certain meds, regardless of enzyme markers. I am approaching with as open a mind as possible because as you say, getting no relief for my anxiety/depression is not a very pleasant fact to look forward to.
Peace, Gary

Gary, I hope all works out well for you. 🙂