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← Return to Being treated for Gleason 9
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Prostate Cancer | Last Active: Feb 23 7:42am | Replies (46)
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@jeffmarc
Hi Jeff
I understand the PSA bounce after radiation, but shouldn't the Orgovyx/Nubeqa combo bring it to undetectable at some point? I've been on them for 9 months. GUO Doc said he was looking for nadir sometime this Spring which is my next blood test.
Replies to "@jeffmarc Hi Jeff I understand the PSA bounce after radiation, but shouldn't the Orgovyx/Nubeqa combo bring..."
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@mjp0512
Yes, those two drugs should bring your PSA down to undetectable. You didn’t mention it in the last message. Had to go back to seven months ago to see you mentioning it.. Has your doctor mentioned that you might be Castrate resistant? When your PSA doesn’t drop to undetectable after you’ve been on drugs like that for this long castrate resistant is a possibility.
I became castrate resistant to Lupron, but I’m now on Orgovyx And it alone can’t keep my PSA down, but Nubeqa Does do it for me. I’ve been undetectable for 27 months after 16 years. Before I was on Nubeqa I was on Zytiga for 2 1/2 years and my PSA was only undetectable for one month. What I’m getting at is the drugs can work differently for some people.
I think your only option here is to wait a little bit longer and see what the next blood test shows. If your PSA keeps rising, you can get a PSMA pet test and see if you’re still light up in a lot of spots. If so, you could get Pluvicto.
I am a little puzzled, though, you mentioned lighting up quite a bit on the PET test and yet you had radiation. Radiation isn’t designed to remove multiple metastasis, The treatment for that is chemo or Pluvicto. Am I missing something here?