Thank you for your info. I also have diminishjed kidney function and the doctor was trying to keep my blood pressure as close to normal as possible for that condition along with the diastolic dysfunction. I have checked all the blood meds out and they all seem to help with the diastolic dysfunction. Could you tell me your concerns about taking the 4 meds? The doctor who prescribed them was the nephrologist who also consulted with the cardiologist. It is all very tricky. Thank you for any additional input you have.