@jackiet you should have no digestive problems with the opioids themselves. What I think might be your problem is the lactose in the pills. Are you lactose intolerant by any chance? People forget to check the ingredients of their medicine. The white pill oxycodone gives me a stomach ache, which is rectified by taking a Lactaid pill. Everyone thinks that cheap medicines are so great. I just find that cheap medicines bring a lot of ingredients that we can’t tolerate in our older age one of them being lactose the other being gluten. There’s a white pill oxycodone a pink pill oxycodone (I tolerate those very well) and there is the Percocet, which I mainly have used for 25 years and have no digestive problems. Sometimes when the pharmacies change brands, it causes a problem and I always find that the problem is in the ingredients which are overlooked by the cheap proliferation of medicine these days. I hope that helps you PS you could also have a condition called SIBO small intestinal bacterial overgrowth, which requires a targeted antibiotic called Xifaxan. Periodically I have to take that and then I can go back to being a somewhat normal person and just taking the Lactaid pills. I hope that helps you.