@hazely I have been on Trelegy 200 for about 2 1/2 years . I was diagnosed with level 4 Emphysema the first time I went to seek help . I was put on 24/7 oxygen at 4 liters . And Trelegy 200. They asked me if I felt better using Trelegy. I honestly could tell no difference . I am still on 4 liters and the Trelegy. I get winded if I try to do much. I have to pace myself and avoid sob. There are many changes one has to make . I don’t use fitted sheets . Two flat sheets are much easier . I don’t tuck anything . The hardest thing for me is dressing. All the pulling and stretching moves we make to get a garment off or on. I use my oxymeter anytime I feel sob or if I feel my pulse go up . My Dr told me that if my oxymeter reads 88 or lower, then I am to stop. , sit and wait for it to regain to 90 or 91. He tells me brain and body damage starts to happen at 88. . Those moments add up . So I try very hard to avoid over doing any actions . If an action takes too much energy , I try to change my method . We all are having hard times . Bless You , I wish you the best !!! Crystalena