I used Trelegy for ~3 yrs. Following instructions to RINSE after use I found after 6 months and a dentist visit I had SEVEN CAVITIES costing $1800 for fix. ZERO cavities for 5 years prior to starting Trelegy. Dentist recommended BRUSHING rather than just rinsing & thereafter seemed to correct that problem. COVID shot #5 in Oct 2022 appeared to correct my breathing problems and during 1st 3 months of 2023 I was able to wean myself off of Trelegy. No problems for 2 years but appears I now may need to return to use because of asthma caused by allergies but USA price is ABSOLUTELY OUT OF REACH at $700+ per month living on social security with no generic until at least 2030!