@mmsm I was on Effexor XR for many years and stopped taking it as well. I did experience brain tremors and many other symptoms. I also relapsed. This was back in the early 2000's. I swore I would never get back on it. After I got sober in 2017, I did really well until many things happened, traumatic things. I went into a depression hole. I did NOT want to have to take anything, but I had to get out of the hole. My doctor started me on duloxetine (generic Cymbalta) it is an SNRI. I am on the lowest dose, 30 mg. It has helped and it also helps with some of my Long COVID symptoms. I am not advocating for anyone taking anything, just wanted to share my experience. I hope the supplements go well. There is a lot to be said for nature and what diet and exercise, etc., can do. Vitamin B12 injections have also helped me. Thank you for posting.