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My TRIMIX experience

Posted by maverick75 @maverick75, Jan 4 9:27am

I've been using Trimix for about six months with outstanding results. It did take some experimentation to figure out the best way to make it work for me. With hopes that it may help others, here's what I discovered using this medication: (BTW, I'm 71, one year post SBRT and 4 months Orgovyx)
- I have had to use the oral antidote several times (works well) in the early dose experimentation days for super hard erections lasting more than three hours (4tablets of 30 mg pseudoephedrine. Don't make the mistake of buying the extended release pseudoephedrine tabs). Make sure you have this on hand before you start this medication!
- I had to find the sweet spot for the injection site and depth. For me turns out to be the 10 and 2 o'clock position with the 1/2" needle almost fully inserted around mid-shaft.
- Shelf life on the Trimix in the refrigerator is limited. I can definitely see a difference in the results at the 3-4 week period. For me, it became pretty useless after 4 weeks, even at a higher dose. To help extend the life, I now fill all syringes with the needed dose as soon as I get the medication and immediately place all syringes into the freezer until needed. Now, I take a syringe out about 30 min before needed and it's ready to go. This is working well and my pharmacist said this should extend the shelf-life to 6 months or more.
- After injecting, massage the entire penis and base to help distribute the medication throughout the muscle structure. This will help significantly.
- Stand for the first 5-10 minutes after injection as gravity aids in the blood flow into the penis.
This medication has been a lifesaver for me. I was afraid I'd never see a useful erection again. Now, I'm back to 18 in that regard-- actually better than 18 as my erection stays hard even after an orgasm! Best of luck guys! Be aware that your partner may hide your medication if you use it to often. (-:

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

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jime51 | @jime51 | Sep 26 2:56pm
In reply to @tj1967 "@jime51 I’ve got a lot of experience with VEDs because I refused to give up on..." + (show)
Profile picture for tj1967 @tj1967

@jime51 I’ve got a lot of experience with VEDs because I refused to give up on having a sex life after surgery, and it took forever to finally get my Trimix appointment. I actually use two different VEDs for different reasons. One is mainly for daily rehab, and the other is for sex.

The Soma Therapy (see link below) works great for daily blood flow exercises. I don’t bother with the tension bands because they break after a few uses and cost too much to replace. Instead, I just use it to pull blood into my penis, hold it for a few minutes, release, and repeat for about 10 to 15 minutes a day. It’s basically a workout to keep blood moving and the tissue healthy.

The Vacurect (see link below) is the one I use before sex. It’s really easy to use and holds the erection better than the Soma Therapy. The only tricky part is removing the tension band afterward. The best way I’ve found is to gently squeeze your penis to push blood out of it while stretching the band. It takes a minute or two, but it works.

I’m starting Trimix tonight and hoping I don’t get any burning. I’ll still keep using both VEDs between injections and for daily rehab. Maybe it’s overkill, but sex is important to me and my wife, and I’m doing everything I can to make sure things keep working.

Soma Therapy: https://augustams.com/product/soma-therapy-otc-manual-system/

Vacurect: https://anactivelife.com/products/vacurect-1002-otc-ved-pump

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@tj1967 Thank you!

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dgd1953 | @dgd1953 | Sep 27 9:04am
In reply to @tj1967 "I had my first Trimix appointment yesterday and it went really well. Good news, I did..." + (show)
Profile picture for tj1967 @tj1967

I had my first Trimix appointment yesterday and it went really well. Good news, I did not have to inject at the office!!!! I answered a few questions, read through a short pamphlet about the injections, and the nurse walked me through everything, including how to inject and how to store the vials.
She told me to start at 5 ml at home and see what happens. Since I lost one set of nerves after my prostate surgery in January, she said not to expect a full erection with that small of a dose. The plan is to start low and increase slowly. I’ll begin with 5 ml, and if nothing happens, I’ll go up to 10 ml next time and keep adjusting until I notice some response. Once I finish the small trial vial, which has enough for three shots, I’ll check back in with her to report what happened. Once I find the ideal dose that produces an erection for no more than an hour, she will set me up with prescription service which will be handled through MenMD.
Tonight will be my first test, and I can't wait. The vacuum pump has been working for me, but it’s just not the same. When you use those tension rings, it's like your erection is attached to a swivel joint! ugh!

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@tj1967 5 ml is a LOT! I’m assuming you meant 0.5 ml which is the typical starting dose.

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dgd1953 | @dgd1953 | Sep 27 9:09am
In reply to @jime51 "I really appreciate your detailed explanation. The Sudafed recommendation came in handy. Unfortunately, I am one..." + (show)
Profile picture for jime51 @jime51

I really appreciate your detailed explanation. The Sudafed recommendation came in handy. Unfortunately, I am one of those patients who reacts poorly to Trimix, with the prostaglandin/alprostadil ingredient causing significant pain during the erection and eliminating the pleasure of intercourse. I have asked my oncologist for a Bimix prescription to try, leaving out that chemical but also likely reducing the effectiveness. I'd rather not do without sex the entire two years I'm on Orgovyx and beyond that to recovery.

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@jime51 I initially had the same discomfort with Trimix. I learned that Trimix comes in a variety of concentrations and switched to a low alprostadil formulation (Trimix #6 at menMD) which is working well without the pain. I do combine the injections with ved use for optimal effect. Good luck.

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Profile picture for rbtsch1951
rbtsch1951 | @rbtsch1951 | Sep 27 10:41am
In reply to @tj1967 "@jime51 I’ve got a lot of experience with VEDs because I refused to give up on..." + (show)
Profile picture for tj1967 @tj1967

@jime51 I’ve got a lot of experience with VEDs because I refused to give up on having a sex life after surgery, and it took forever to finally get my Trimix appointment. I actually use two different VEDs for different reasons. One is mainly for daily rehab, and the other is for sex.

The Soma Therapy (see link below) works great for daily blood flow exercises. I don’t bother with the tension bands because they break after a few uses and cost too much to replace. Instead, I just use it to pull blood into my penis, hold it for a few minutes, release, and repeat for about 10 to 15 minutes a day. It’s basically a workout to keep blood moving and the tissue healthy.

The Vacurect (see link below) is the one I use before sex. It’s really easy to use and holds the erection better than the Soma Therapy. The only tricky part is removing the tension band afterward. The best way I’ve found is to gently squeeze your penis to push blood out of it while stretching the band. It takes a minute or two, but it works.

I’m starting Trimix tonight and hoping I don’t get any burning. I’ll still keep using both VEDs between injections and for daily rehab. Maybe it’s overkill, but sex is important to me and my wife, and I’m doing everything I can to make sure things keep working.

Soma Therapy: https://augustams.com/product/soma-therapy-otc-manual-system/

Vacurect: https://anactivelife.com/products/vacurect-1002-otc-ved-pump

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@tj1967 was the Vacurect device recommended by your physician, or did you choose it on your own? There are so many VEDs on the market, but not all are certified by the FDA. How does one select?

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dgd1953 | @dgd1953 | Sep 28 8:28am
In reply to @rbtsch1951 "@tj1967 was the Vacurect device recommended by your physician, or did you choose it on your..." + (show)
Profile picture for rbtsch1951 @rbtsch1951

@tj1967 was the Vacurect device recommended by your physician, or did you choose it on your own? There are so many VEDs on the market, but not all are certified by the FDA. How does one select?

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@rbtsch1951 There are some helpful YouTube videos done by urologists where they discuss the pros and cons of various VEDs as well as how to use them. menMD produced some, but there are others too.

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tj1967 | @tj1967 | Sep 29 8:43am
In reply to @dgd1953 "@tj1967 5 ml is a LOT! I’m assuming you meant 0.5 ml which is the typical..." + (show)
Profile picture for dgd1953 @dgd1953

@tj1967 5 ml is a LOT! I’m assuming you meant 0.5 ml which is the typical starting dose.

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@dgd1953 Yes, my apologies! I’m still getting the hang of this Trimix routine. The starting dose was actually 0.05 ml (5 units), and I’ll be increasing gradually from there until it’s effective. I mistakenly thought 5 units meant 5 ml. Thanks for catching that!

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tj1967 | @tj1967 | Sep 29 8:49am
In reply to @rbtsch1951 "@tj1967 was the Vacurect device recommended by your physician, or did you choose it on your..." + (show)
Profile picture for rbtsch1951 @rbtsch1951

@tj1967 was the Vacurect device recommended by your physician, or did you choose it on your own? There are so many VEDs on the market, but not all are certified by the FDA. How does one select?

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@rbtsch1951 No, my doctor didn’t recommend either one. I’m sure he would have at a follow-up visit down the road, but I wanted to move quickly with my recovery, so immediately after surgery I went ahead and ordered one after doing my own research and reading a lot of reviews online. After breaking a few tension bands with the Soma Therapy, I went ahead and ordered the Vacurect and now use both.

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tj1967 | @tj1967 | Sep 30 3:27pm
In reply to @maverick75 "When I was new to Trimix, I found I had that stinging when I injected it..." + (show)
Profile picture for maverick75 @maverick75

When I was new to Trimix, I found I had that stinging when I injected it in the wrong area. In my case, it was too deep. I found for me, I have to insert the needle at the 10 or 2 o'clock position and insert the length of the needle but just until the syringe reaches the skin (no depression of the skin). After having done it so many times now, I can feel the slight resistance when the needle penetrates the erectile tissue. After the injection, make sure you massage your penis and the base area to distribute the medication and stand while you are doing this and for the next 5-10 min. Don't give up.

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@maverick75
My 1st injection the another night worked great. I didn't push the needle in as far as it should go, but still had 3/4 of an erection with small dose. 48 hours later, 2nd attempt and nothing happened. I don't think I went deep enough with the needle or missed the target area altogether. That was really frustrating. I'm still getting used to that initial feeling of needle going in with slight burn when you inject the Trimix. Hoping for some success tonight just have to sink that needle....youch!

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2 replies
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tomf | @tomf | Oct 1 6:01am
In reply to @tj1967 "@maverick75 My 1st injection the another night worked great. I didn't push the needle in as..." + (show)
Profile picture for tj1967 @tj1967

@maverick75
My 1st injection the another night worked great. I didn't push the needle in as far as it should go, but still had 3/4 of an erection with small dose. 48 hours later, 2nd attempt and nothing happened. I don't think I went deep enough with the needle or missed the target area altogether. That was really frustrating. I'm still getting used to that initial feeling of needle going in with slight burn when you inject the Trimix. Hoping for some success tonight just have to sink that needle....youch!

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@tj1967 after my initial purchase of doses, a doctor from MenMD called me to ask how the injections were going. My answer was similar to yours. He said to make sure that, if I was in the correct "clock" position, then to make sure I pushed the needle in far enough to make a dimple in my skin before injecting the medicine. I haven't had a bad injection since.

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babyboomer1960 | @babyboomer1960 | Oct 21 8:42pm
In reply to @florida11 "I use the vacuum pump as well 2-3 times a week for 20 minutes each time...." + (show)
Profile picture for florida11 @florida11

I use the vacuum pump as well 2-3 times a week for 20 minutes each time. I only use 2-3 units of trimix out of a 100 unit syringe and get several hour erections . I was told by my urologist that specializes in this topic to use the vacuum pump to keep it healthy. It seems to make a difference.

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@florida11 what vacuum pump do you use?

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