I have a question similar to one posted recently by @bettersleep68.
I’m 62 yr. old, favorable risk AML, and have completed induction and four cycles of chemo consolidation therapy. While I’m in morphological remission, I tested positive for measurable residual disease (MRD) and am considering a venetoclax/ azacitidine maintenance therapy.
Questions for anyone whose used these medicines in combination (or just one) for such therapy.
1. Had you undergone a BMT prior to receiving this therapy?
2. Did you experience any neutropenic fevers? (fever>100.4 combined with low white blood cell count, which usually requires hospitalization for potential infections.)
3. Did your hemoglobin levels dip to the point where you needed blood transfusions and/or became severely anemic?
4. How many cycles did you undergo?
5. During the overall treatment process, did your hemoglobin and ANC values increase to the point at any time so that your life achieved any sense of normalcy, e.g. could you exercise, go out in public, etc.
6. Did treatment alter your MRD status from positive to negative?
I have a question similar to one posted recently by @bettersleep68.
I’m 62 yr. old, favorable risk AML, and have completed induction and four cycles of chemo consolidation therapy. While I’m in morphological remission, I tested positive for measurable residual disease (MRD) and am considering a venetoclax/ azacitidine maintenance therapy.
Questions for anyone whose used these medicines in combination (or just one) for such therapy.
1. Had you undergone a BMT prior to receiving this therapy?
2. Did you experience any neutropenic fevers? (fever>100.4 combined with low white blood cell count, which usually requires hospitalization for potential infections.)
3. Did your hemoglobin levels dip to the point where you needed blood transfusions and/or became severely anemic?
4. How many cycles did you undergo?
5. During the overall treatment process, did your hemoglobin and ANC values increase to the point at any time so that your life achieved any sense of normalcy, e.g. could you exercise, go out in public, etc.
6. Did treatment alter your MRD status from positive to negative?
Answering your questions in numerical order.
1. Declined BMT
2.Never ran a fever after induction therapy.
3.Yes I required both blood platelet and potassium transfusions.
4. I believe there were 4 transfusions in total over the first 3 months after induction therapy.
5. I have achieved normal ANC, Platelet, Hemoglobin numbers for the first time since diagnosis in March 2024. Treatment is Dacogen and Ventclextca . I am working 2 days a week and my July 2025 MRD didn’t find any of my mutations (FLT3, NPM1). I get 1 chemo treatment in my port every 5 weeks and take chemo pills 2 days (chemo port day and the next day).
6. I have gone from 90% blasts when diagnosed to no evidence of disease with latest MRD test. I will be tested again in November.
I wish everyone dealing with AML would have the outcome I am currently experiencing. My team has worked using my weekly blood draws to get my treatment from 5 consecutive days of port Chemo and 14 days of chemo pills down to 1 day port chemo and 2 days chemo pills. I feel really great overall!
Answering your questions in numerical order.
1. Declined BMT
2.Never ran a fever after induction therapy.
3.Yes I required both blood platelet and potassium transfusions.
4. I believe there were 4 transfusions in total over the first 3 months after induction therapy.
5. I have achieved normal ANC, Platelet, Hemoglobin numbers for the first time since diagnosis in March 2024. Treatment is Dacogen and Ventclextca . I am working 2 days a week and my July 2025 MRD didn’t find any of my mutations (FLT3, NPM1). I get 1 chemo treatment in my port every 5 weeks and take chemo pills 2 days (chemo port day and the next day).
6. I have gone from 90% blasts when diagnosed to no evidence of disease with latest MRD test. I will be tested again in November.
I wish everyone dealing with AML would have the outcome I am currently experiencing. My team has worked using my weekly blood draws to get my treatment from 5 consecutive days of port Chemo and 14 days of chemo pills down to 1 day port chemo and 2 days chemo pills. I feel really great overall!
I take vidaza 3 injections per 28 days(was 5 times )...I take venetoclax 100mg daily....my blasts are down and labs are all normals...but I have 4 ugly mutations .....thanks for your response...
I take vidaza 3 injections per 28 days(was 5 times )...I take venetoclax 100mg daily....my blasts are down and labs are all normals...but I have 4 ugly mutations .....thanks for your response...
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Please answer...thanks
@bettersleep68 : I have the same question and am following your post.
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1 ReactionI have a question similar to one posted recently by @bettersleep68.
I’m 62 yr. old, favorable risk AML, and have completed induction and four cycles of chemo consolidation therapy. While I’m in morphological remission, I tested positive for measurable residual disease (MRD) and am considering a venetoclax/ azacitidine maintenance therapy.
Questions for anyone whose used these medicines in combination (or just one) for such therapy.
1. Had you undergone a BMT prior to receiving this therapy?
2. Did you experience any neutropenic fevers? (fever>100.4 combined with low white blood cell count, which usually requires hospitalization for potential infections.)
3. Did your hemoglobin levels dip to the point where you needed blood transfusions and/or became severely anemic?
4. How many cycles did you undergo?
5. During the overall treatment process, did your hemoglobin and ANC values increase to the point at any time so that your life achieved any sense of normalcy, e.g. could you exercise, go out in public, etc.
6. Did treatment alter your MRD status from positive to negative?
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Like -
Helpful -
Hug
1 ReactionAnswering your questions in numerical order.
1. Declined BMT
2.Never ran a fever after induction therapy.
3.Yes I required both blood platelet and potassium transfusions.
4. I believe there were 4 transfusions in total over the first 3 months after induction therapy.
5. I have achieved normal ANC, Platelet, Hemoglobin numbers for the first time since diagnosis in March 2024. Treatment is Dacogen and Ventclextca . I am working 2 days a week and my July 2025 MRD didn’t find any of my mutations (FLT3, NPM1). I get 1 chemo treatment in my port every 5 weeks and take chemo pills 2 days (chemo port day and the next day).
6. I have gone from 90% blasts when diagnosed to no evidence of disease with latest MRD test. I will be tested again in November.
I wish everyone dealing with AML would have the outcome I am currently experiencing. My team has worked using my weekly blood draws to get my treatment from 5 consecutive days of port Chemo and 14 days of chemo pills down to 1 day port chemo and 2 days chemo pills. I feel really great overall!
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10 Reactions@sonieaml —Wow! That’s incredible. I’ll have to share your treatment plan with my oncologist/hematologist. Thanks!
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1 Reaction@bettersleep68, I expanded the title of your discussion to reflect your question to help others find it. How are you doing on venetoclax orally?
I take vidaza 3 injections per 28 days(was 5 times )...I take venetoclax 100mg daily....my blasts are down and labs are all normals...but I have 4 ugly mutations .....thanks for your response...
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2 Reactions@bettersleep68 — are your blasts down enough so that you’re considered in “remission?”
I
I hope my bone marrow on Monday.. shows that I am in remission but worry about the mutations
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