@sdugan001 What a bummer you are experiencing these symptoms. Although Brinsupri has not caused any issues in me so far, stomach issues and/or headache can occur when you first start it according to my doctor. That said, moxifloxacin alone can cause stomach discomfort, as can any antibiotic. I agree with @pacathy that a sputum culture is critical. Personally, I would not start another antibiotic until I dropped off a sputum sample for culture. I hope you feel better soon!

FYI – so far my experience with Brinsupri has been positive. I’m entering my 4th week and my previous random hacking cough jags are now rare, with mucus lighter in color and less of it, and clearance time seems quicker than before starting Brinsupri. I've just now come from a dental appointment (a restoration, which was at least 2 hours in a supine position) and did not cough once!