I feel your pain. Here are a few things I have done over the last 12 years. 1)Airway clearance: I use my vest on days I can’t do some aerobic exercise that accomplishes the same thing: for me, that is cycling a minimum of 7 miles or walking 30 minutes. (Due to past injuries, I am a pathetically slow walker.) I don’t know what shape you are in, but if you can exercise, that kills two birds (clearance and exercise) with one stone. 2) Do you really need all the hearing exams? I resigned myself to hearing loss due to Tobramycin years ago. My ENT. said it would happen no matter what (it has not been nearly as bad as he predicted), so why bother? 3) I asked my pulmonologist for something I could use on days, especially evenings, when the nebulizing thing was too much of a burden. He gave me Dulera, which I use on average once or twice/week, and more when traveling if I am not experiencing an exacerbation or otherwise feeling well. 4) I bit the bullet and bought a Pari eRapid nebulizer. That sucker is fast and easy to maintain. Nebology has great prices and sales. (I got mine for $700 or so.) Nebulizing 4 vials and sanitizing usually does not take more than 35 minutes. 5)Talk to all your doctors about the time suck. I have it down to less than 24 waking hours/wk when I feel good. (I am counting an average exercise load of 1.5 hr a day, though when time permits, I do a lot more— it has great mental and physical benefits. I could probably cut back without hurting my lungs. I wish more people would complain to their docs about it. Mine often come up with alternatives when I say I need to cut down the time. Make sure they explain why they need all the tests & appointments whose value you question. 6) Again, exercise. When you can, stairs instead of lifts, swimming, biking, golf without a cart, when your spouse or partner is boring you with shopping, walk around the mall, parking lot or street, and wear an Apple Watch, Garmin, or something else that will give you meaningful info about your progress.