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Since early childhood, I have experienced significant exercise intolerance, with an inability to walk distances greater than 50 meters, climb stairs or inclines, ride a bicycle, participate in gymnastics, or lift heavy objects.
After 65 years, a final diagnosis from the UK: Post-Polio.

In addition, confirmed diagnoses:
1961 psoriasis diagnosis
1964 ectopic pregnancy / left salpingectomy
1964 Dermatological Clinic Augsburg Psoriasis
1967 Derma- Clinic Nuremberg mainly treated with cortisol ( Volon 40 and Volon 80)
1979 Uterine dysplasia 4/hysterectomy
1980 Diagnosis of low cortisol at the University of Erlangen
1983 extreme migraine - neurology no treatment
1993 PTSD diag-Kaiser Permanente South Sacramento
1998 Diverticulosis and C-Dif - Kaiser Permanente South Sacramento
2000 (US) low cortisol average 4.5 - treatment prednisone
2000 (US) progressive muscle weakness in legs, upper arms and back muscles
2007 (US) low cortisol 1.1 - Endo: treatment prednisone
2008 (US) MRI with contrast Chiari Malformation I
2009 (US) Chiari Malformation I with Decompression Surgery
2011 (US) Hemilaminectomies with posterolateral fusion with pedicle screws
2013 (US) Myalgia (myositis) diagnosis UNMH 2013/15/16 ICD G93.3 CSF
2013 (US) MRI - Stenosis and Tarlov Cyst Spondylitis
2016 (US) OP L4 – L5 (CD)
2016 (US) OP Lumbar spinal hardware infection, Data 4/7/16 Body fluid back lumbar spine superficial GS/CX: very rare growth: bacteremia: Staph epidermidis and Peptostreptococcus , Peptostreptococcus , one colony Staph caprae , Corynebacterium species,” treatment: IV 6 weeks antibiotics Vancomycin
2018 (US) Aortoiliac vascular calcifications are noted.
2020 Germany Scapula ganglion cyst - bilateral, 5 cm 2 Fibrosing /granulomatous processes in the apex of the scapula (MRI) Clinik DON MRI
2020 Germany Myasthenia Gravis / Eaton-Lambert Syndrome??? (Report UNI-Regensburg inconclusive)
2021 Germany COVID-19 and mRNA - BioNTech results: Stevens-Johnson syndrome (SJS)
2021 Germany Rheumatoid arthritis, Thrombosis, jaundice, herpes, urticaria, POTS, PEM, anaphylaxis (Onco: DON)
2021 Germany Corticotropic insufficiency (Endo: Dr. Vlotides Ingolstadt)
2022 UK Post-Polio diagnosis in the UK, Dr. Shaw.
2022 Germany: Antiphospholipid Syndrome, vWillebrand Factor 2 and 5, Lupus, Petechiae, Gene: ACADM

Current Symptoms - but I manage and keep going at the age of 76:

Fatigue: Persistent and profound fatigue with a constant sense of exhaustion, rarely alleviated by rest.
Muscle Weakness: Generalized muscle weakness, particularly in the upper and lower extremities, exacerbated by physical exertion such as lifting, stair climbing, or walking uphill.
Autonomic Symptoms: Diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS), with symptoms including irregular palpitations and significant tachycardia upon standing.
Ocular and Oral: Xerostomia (dry mouth), dry eyes, and episodic visual disturbances in the left eye (described as fogging or blurred focus).
Auditory: Intermittent hearing disturbances with tinnitus affecting the left ear.
DNA: gs191 Impaired NSAID drug metabolism - ADAMTS13 deficiency.
rs12340895(C;G); four times higher odds of developing V617F-positive myelofibrosis (MPN)
Good: rs5848(G;G) lower dementia risk. Lower risk of frontotemporal dementia, alzheimer's disease and parkinson's disease.

Mother: Cushing-Syndrome, vision problems, rheumatoid arthritis - died at age 56
Father: psoriasis, vision problems, rheumatoid arthritis- died at age 80
Brother 1: ALS - died in 2014 age 64
Brother 2: heart attack 2022 age 71

My attitude: "Let battle commence".

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Replies to "Since early childhood, I have experienced significant exercise intolerance, with an inability to walk distances greater..."

@swalex
I am so sorry to read all you have been through, you are a tough cookie!
You have been through the battle and I pray you continue! You sound like a very strong individual after all of this, stay hopeful and continue to choose life and peace in it.

I have also been through a lot with auto immune illness and that of my families.

My son was type1 diabetic at 4yrs old. My daughter was diagnosed with Lupus. My mom and sister were chemically sensitive and sister died at 50 of colon cancer. Mom diagnosed with stage 4 lung cancer just before sister passed away, lost mom at age 68. Dad died of lung caner the year before her. at 69. Neither mom or sis smoked and parents had been divorced since 1972. My daughter recently diagnosed with RA and her son with psoriatic arthritis at 13. We all tested HLA-B27 positive.
I have thoracic scoliosis, psoriatic arthritis, AS has been so painful and really tries everyday to steal my joy, dry eye disease, cervical stenosis, OP@ age 46, and chronic IBS-constipation since childhood. I developed high blood pressure in 2022 and just recently diagnosed with high cholesterol. My glucose runs high and I am on a long list of meds for 64 yrs old. I try to remain positive and eat healthy for the most part. My husband has Dish which is also auto immune related. He has a lot of pain due to stiffening of his cervical spine and bad shoulders, many surgeries as he has over worked and lifted most of his life.
My aunts died of ALS and cancer as well as my G-ma.

I have to decide if I will go on a statin, I don't want to as I researched and see most cause more muscle pain and problems. However I don't want to have heart disease either:/ I am not totally sure what to do as I am on Bimzelix (biologic injection) for AS, Otezla for psoriasis and several other meds for the other problems. Do you take medications for your list of conditions? Any advice regarding statins, or other meds or supplements that have helped you?