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← Return to Brinsupri (aka Brensocatib)
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I have listened to two webinars on Brinsupri so far. But it is still not clear to me what symptoms we might notice improvement in after some time. Do you know? It does not seem clear what the actual benefits are that we might actually notice or experience. The main thing I heard early on was reduced exacerbations.
Replies to "I have listened to two webinars on Brinsupri so far. But it is still not clear..."
@scoop it is a bit disconcerting to me too that the Brensocatib/Brinsupri studies were not more objective in their data collection. Did they have participants measure sputum, or did participants have cough apps to help quantify coughing episodes? These are our daily trials and tribulations. I was even hoping we would hear more from the early research participants. But so far I am not seeing resounding success stories. And the Q and A with Dr. Metersky even left me with more questions about the roll out of the medication to the community pulmonologists.
Reduced exacerbations is the goal of this drug. Continued airway clearance is crucial to this process though. So as I understand the mechanism of brinsupri, there is a reduction in production of the enzyme DPP1 produced by neutrophils which causes the inflammatory process - thus reduction in exacerbations. Staying well longer between infections is what we should notice.
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My understanding is reduced respiratory symptoms, including cough, sputum and exacerbations.