How long does your oncologist have you on ADT?
I had surgery in March 2020. I was undetectable for 3 years, then started to see some PSA. .05.....06 ... Eventually climbed to .25 in Feb/2025, which triggered follow up treatment, starting in Late March 2025. Orgovyx for 6 weeks then 25 radiation treatments which ended 6/25/25. I am scheduled for ADT for 6 months,ending around Oct .1. My question is- is 6 months the norm?
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Opposite rudder. Point cessna down to gain airspeed- you are correct. Lol. Hope this breaks up a PCa conversation for today. I only have 114 TT flying- I m no instructor. Lol
Nubeqa is supposed to have less mental side effects than Xtandi. But Orgovyx is likely causing some of the mental side effects. A speciality cancer pharmacist told me that sometimes Xtandi doesn’t add to the mental side effects because the ADT is already causing them but he also said everyone is different. Wish you both all the best with this.
Yes, I had Gleason 7 so I’m getting 6 months of ADT.
But I envy the “doesn’t bother me” group. The side effect of hot flashes has been just brutal for me. I get one, which happens quite often, and must immediately stop what I’m doing and rush to a fan, drenched in sweat. So I’m really hoping this will be it, although its a little hard to be too optimistic about that outcome.
I am also a Gleason seven. I’ve been on ADT for eight years. I stopped for eight months and I’m back on it again and Getting 7 to 8 hot flashes a day. Yes, the sweat comes down over your eyes and drips into things you’re doing. I have an embrlabs.com wave 2 device I wear my arm to stop hot flashes. When they’re real bad, it just makes them a little less severe, If I can catch them quickly enough, they really don’t get too hot but for going out and doing something, I can’t hit the buttons. When it really helps at night, Stops the hot flashes and sweats at night.
Yesterday I got a depo-provera shot. After my first year of terrible hot flashes, my oncologist mentioned that going on Depo-provera might stop The hot flashes. It sure did, almost completely, stopped them for a couple of years until I went on Zytiga.
The shot lasts about three months And it takes a couple of weeks before it becomes effective.
They say that taking these type of hormones can give you gynecomastia, But I was on this for four years and had almost nothing occur.
With regard to ADT side effects, I would put myself in the category of"
Bad , but not as bad as I thought they would be" and that includes hot flashes , that seem to come on way more frequently whn I am outside in the heat,
I think living with hot flushes on long-term ADT is a combination of 3 things:
1. They become less common (I used to get them just from thinking hard about something).
2. You learn to spot the triggers and early warning signs, and head them off before you're soaked (e.g. peel off a layer, get to a fan early, try relaxation exercises to keep the hypothalamus from firing off on all barrels).
3. You get used to the remaining ones that 1 and 2 don't take care of, so they're less of a disruption.
In just 6–12 months on ADT you don't have time to learn and develop any of this, so it's natural that hot flushes would seem frequent and almost unbearable, but in my own experience they get much easier over time.
And let me add that I'm now deeply embarrassed about that post. I went overboard trying to counter the OP's unfounded fear that ADT would make her husband into a "drooling idiot," and ended up bragging in a way that's not consistent with my personal values. I apologise to everyone for that. Please disregard.
And now, back to our regularly-scheduled programming…
0.01 is very good. That would be a result of "undetectable" on a normal PSA screening test (which typically doesn't go below 0.1), and is near the limit of what even the ultrasensitive PSA test can detect.
Can I ask, what dose of prednisone is everybody on, and how many times a day?
The amount of prednisone being used varies.
Some people take 5 mg once a day
Some people take 2 1/2 mg twice a day
Some people take 5 mg twice a day if they have problems with fatigue
Both five and 10 mg are approved for use with Zytiga
One of the people I mentor through Imerman Angels was on 5 mg and he would wake up in the morning and have to go to back to sleep for two or three hours because he was so exhausted. I asked him to contact his doctor to increase his prednisone to 10 mg and it made a major difference in his fatigue.