How long does your oncologist have you on ADT?

Posted by tjv1156 @tjv1156, 2 days ago

I had surgery in March 2020. I was undetectable for 3 years, then started to see some PSA. .05.....06 ... Eventually climbed to .25 in Feb/2025, which triggered follow up treatment, starting in Late March 2025. Orgovyx for 6 weeks then 25 radiation treatments which ended 6/25/25. I am scheduled for ADT for 6 months,ending around Oct .1. My question is- is 6 months the norm?

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

@northoftheborder

"what to when Cessna stalls and right wing falls with nose of aircraft pointing down"

Ailerons neutral. Correct with opposite rudder first, then yoke forward to break the stall. Increase power and gently recover to level flight.

Next question, instructor? 😉

(I could have included closing the throttle right after ailerons neutral, but that kind of stall usually happens on approach when you're already at low power, so there's no point making it more complicated than it needs to be.)

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Opposite rudder. Point cessna down to gain airspeed- you are correct. Lol. Hope this breaks up a PCa conversation for today. I only have 114 TT flying- I m no instructor. Lol

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@mumpmom

Thank you for that information. My husband has stage four metastatic prostate cancer Some in the lower back and a lymph node. He is an 84-year-old organic gardener/double E design engineer. He has been on Orgovyx and Xtandi since the end of February. His PSA had risen over a year from three, to 11. 19 biopsies all came back carcinoma. He did have chirp surgery early in March, and he needed two blood transfusions and was in the hospital, a place. He has never been in his life, for four days. His urologist said he had a huge prostate, and there was a lot of bleeding He does have hot flushes and was having chills after that, but they seem to have stopped. What I am, noticing is some cognative changes. Very subtle but noticeable to me, I’m his wife. He had a cystoscopy yesterday as they found blood in his urine two weeks ago. His bladder is clear, thank God. We’re seeing his oncologist to discuss change in medication. Lupron injection was mentioned. His urologist suggested we talk to the oncologist, but he also agreed with me, that it is easier to stop a pill, than to wait six months, and even longer,if my husband has more severe reactions to the Lupron injection. He has not had any other procedures, just two PET scans, in the last six months. We went to Dana Farber for a second opinion. His doctor there wanted his PSA at .02 he is there, and last PSA, two weeks ago was .01. Has anyone dealt with the cognitive issues? my husband‘s concerned that he’s going to be a drooling, unresponsive vegetable. I still think it’s too early to know since it all has come as a huge shock to both of us and mentally dealing with this is difficult. He was active 15 hours a day, at his age trimming trees, putting a new roof on our shed and cultivating in his John Deere tractor 3 acres of property here. His urologist told him, “it’s quality of life versus medication’s.”

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Nubeqa is supposed to have less mental side effects than Xtandi. But Orgovyx is likely causing some of the mental side effects. A speciality cancer pharmacist told me that sometimes Xtandi doesn’t add to the mental side effects because the ADT is already causing them but he also said everyone is different. Wish you both all the best with this.

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@northoftheborder

Yeah, "forever" means either

1. Until they figure out a better approach to long-term stage-4 prostate cancer management, or
2. We die (possibly from something else).

I also sometimes use the phrase "ADT lifer" to describe our situation. I don't know about you, but I'm pretty used to living with ADT + Apalutamide now. For me, the side-effects are just minor annoyances rather than real issues, like they sometimes could be during the first 12–18 months.

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Yes, I had Gleason 7 so I’m getting 6 months of ADT.

But I envy the “doesn’t bother me” group. The side effect of hot flashes has been just brutal for me. I get one, which happens quite often, and must immediately stop what I’m doing and rush to a fan, drenched in sweat. So I’m really hoping this will be it, although its a little hard to be too optimistic about that outcome.

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@rob275

Yes, I had Gleason 7 so I’m getting 6 months of ADT.

But I envy the “doesn’t bother me” group. The side effect of hot flashes has been just brutal for me. I get one, which happens quite often, and must immediately stop what I’m doing and rush to a fan, drenched in sweat. So I’m really hoping this will be it, although its a little hard to be too optimistic about that outcome.

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I am also a Gleason seven. I’ve been on ADT for eight years. I stopped for eight months and I’m back on it again and Getting 7 to 8 hot flashes a day. Yes, the sweat comes down over your eyes and drips into things you’re doing. I have an embrlabs.com wave 2 device I wear my arm to stop hot flashes. When they’re real bad, it just makes them a little less severe, If I can catch them quickly enough, they really don’t get too hot but for going out and doing something, I can’t hit the buttons. When it really helps at night, Stops the hot flashes and sweats at night.

Yesterday I got a depo-provera shot. After my first year of terrible hot flashes, my oncologist mentioned that going on Depo-provera might stop The hot flashes. It sure did, almost completely, stopped them for a couple of years until I went on Zytiga.

The shot lasts about three months And it takes a couple of weeks before it becomes effective.

They say that taking these type of hormones can give you gynecomastia, But I was on this for four years and had almost nothing occur.

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@rob275

Yes, I had Gleason 7 so I’m getting 6 months of ADT.

But I envy the “doesn’t bother me” group. The side effect of hot flashes has been just brutal for me. I get one, which happens quite often, and must immediately stop what I’m doing and rush to a fan, drenched in sweat. So I’m really hoping this will be it, although its a little hard to be too optimistic about that outcome.

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With regard to ADT side effects, I would put myself in the category of"
Bad , but not as bad as I thought they would be" and that includes hot flashes , that seem to come on way more frequently whn I am outside in the heat,

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@rob275

Yes, I had Gleason 7 so I’m getting 6 months of ADT.

But I envy the “doesn’t bother me” group. The side effect of hot flashes has been just brutal for me. I get one, which happens quite often, and must immediately stop what I’m doing and rush to a fan, drenched in sweat. So I’m really hoping this will be it, although its a little hard to be too optimistic about that outcome.

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I think living with hot flushes on long-term ADT is a combination of 3 things:

1. They become less common (I used to get them just from thinking hard about something).

2. You learn to spot the triggers and early warning signs, and head them off before you're soaked (e.g. peel off a layer, get to a fan early, try relaxation exercises to keep the hypothalamus from firing off on all barrels).

3. You get used to the remaining ones that 1 and 2 don't take care of, so they're less of a disruption.

In just 6–12 months on ADT you don't have time to learn and develop any of this, so it's natural that hot flushes would seem frequent and almost unbearable, but in my own experience they get much easier over time.

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@bluegill

Dang, I want a brain transplant with North.

I had been doing OK during my 4th year on Eligard, but then recent HDR Brachy + doubling the dosage of Flowmax + starting Xtandi is kicking my butt. Yesterday I took 4 naps. A few days ago I took my morning shower twice. I do still remember my wife's name, though.

I'll be chatting with my Mayo doctor in about a month, and if things aren't improving by then, I'll ask him about Nubeqa or other options.

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And let me add that I'm now deeply embarrassed about that post. I went overboard trying to counter the OP's unfounded fear that ADT would make her husband into a "drooling idiot," and ended up bragging in a way that's not consistent with my personal values. I apologise to everyone for that. Please disregard.

And now, back to our regularly-scheduled programming…

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@mumpmom

Thank you for that information. We’ll discuss with my husband‘s oncologist next week. The main concern is the rise in the PSA. Dana Farber was not happy until he went down to 0.02. (If I’m printing that correctly). It is now at 0.01. They told him the chance of spreading at a higher number, was likely. He was diagnosed on Valentine’s Day, of this year, 2025, been on the medication’s as of 1 March.

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0.01 is very good. That would be a result of "undetectable" on a normal PSA screening test (which typically doesn't go below 0.1), and is near the limit of what even the ultrasensitive PSA test can detect.

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Can I ask, what dose of prednisone is everybody on, and how many times a day?

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@rklinke11

Can I ask, what dose of prednisone is everybody on, and how many times a day?

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The amount of prednisone being used varies.

Some people take 5 mg once a day
Some people take 2 1/2 mg twice a day
Some people take 5 mg twice a day if they have problems with fatigue

Both five and 10 mg are approved for use with Zytiga

One of the people I mentor through Imerman Angels was on 5 mg and he would wake up in the morning and have to go to back to sleep for two or three hours because he was so exhausted. I asked him to contact his doctor to increase his prednisone to 10 mg and it made a major difference in his fatigue.

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