I was diagnosed w/systemic Lupus at the age of 41. After seeing many Rheumatologist over the years, it has been a frustrating journey to find the right doctor and care for me. They don't listen to you! Too many years on prednisone has made by bones worse. I have had times when my ANA was positive and times when it's been negative. I am now 65 and doing well managing my arthritic symptoms with supplements and Acupuncture. However, I did a Reclast bone density infusion in June and it was the worst time I have ever felt the way I did. My hands and elbows swelled up so bad I couldn't touch my face. So they had to prescribe Prednisone (the one bad drug that really helps) to calm my auto immune response down. It has taken almost 3-4 weeks for my hands and elbow to recover. Not doing Reclast again. Be your own advocate is what I have learned over the years. If they don't help you, then find someone who will.