Hi Geraldine. My situation is kind of similar to yours. Started the Big 3 after multiple positives for Mac, had a few negative sputum results, and now the last two tests have been positive. Grrr! ID doctor is considering adding clofazamine or bedaquiline, but not amikacin since the bug tested resistant. Also not sure what to do, other than continue with airway clearance and frequent AFB sputum tests, about one every 4-6 weeks. NTM bugs are sometimes hard to eradicate. I wish you the best of luck.