I have been diagnosed for almost 6 years but had no symptoms until last August. I've now completed 4 of 6 scheduled treatments with "FCR" which is considered the "gold standard" for initial CLL treatment although the treatment may be different based on the patient's individual condition and/or circumstances. A CT scan after my 3rd cycle showed very encouraging progress/results. Side effects have not been bad; my clinic is very aware of them, and they pre-treat for the common ones so it really hasn't been bad. I still have most of my hair. The worst part for me is the Neulasta side effects which include aching bones for 1-2 days, but it's certainly tolerable. Chemo effects are cumulative, so the fatigue/weakness has gotten more pronounced in the last couple months. I had a port implanted in my chest thru which the drugs are infused - it makes the chemo treatments much easier because I get stuck only once each cycle and never a problem with finding/hitting/blowing a vein. Good luck; let me know if I can help further.